Scinus Cell Expansion Netherlands B.V. ADH-01-01 Adherent Bag

For the adherent cell culture inside the SCINUS the Adherent Bag is used. ThisAdherent Bag is intended exclusively for use with the SCINUS.The SCINUS is a closed, controlled bioreactor system for automated cellcultivation. Combined with the Adherent Bag, it allows large-fold cell expansionwithout passing the cells due to its unique expansion technology. The SCINUSis operated by a controller, which is accessible through an integrated graphicaluser interface (GUI).The unique combination of the rocker, roller, and Adherent Bag ensures ahomogenous environment with minimal levels of shear forces. The roller on topof the rocker enables the expansion of the available culture volume and surfacearea. The pH and dissolved oxygen (DO) levels are measured by integratedsensors in the Adherent Bag and are controlled with the controller software.The carboxygenator ensures that the set points are maintained within thedesired bandwidths.For the culture of adherent cells, the Adherent Bag must be installed in the SCINUS. The AdherentBag contains the culture bag and the corresponding weldable tubing set.One of the unique features of the Adherent Bag is the gradual expansion of thecell culture volume. The volume can be increased from a minimal volume of 0.1 Lto 1.4 L to accommodate the growing cell population.